Tag Archive for 'inflammatory chemokine CXCL5'

Inflammation and obesity linked again


Regular readers of the Optimal Body Weight News & Reviews column may remember articles on the Zone Diet and the Perricone Weight Loss Diet, where the authors of these anti-inflammatory diets explained that obesity and inflammation go hand in hand. There may be differences in interpretation as to how it comes about, and the best approach to address it; but they both recognize the link between inflammation and obesity.

In both of these books, links between obesity and a number of diseases, including general fatigue, headaches, cancers and arthritis are also highlighted. Please note that while these two (Zone and Perricone) diets are discussed in this article about the link between inflammation and obesity, they are not necessarily the only two anti-inflammatory diets on the market, merely two of the more well-known weight loss programs focused on inflammation.

Now, it appears that a new study published in the April 2009 issue of “Cell Metabolism” may support at least some of these claims. While this study does not even touch on the effectiveness of any of the anti-inflammatory diets with regards to weight loss, it found clear evidence that an inflammatory chemokine (structurally related signaling proteins that are secreted by cells) called “CXCL5” rises and falls with obesity and subsequent weight loss in humans, and of course…mice.

This same inflammatory factor was already linked in previous studies to several diseases, including pulmonary disease, lung cancer, and arthritis. Now that it is also so clearly linked to obesity, it is also very likely that it may be responsible for insulin resistance that accompanies obesity.
Continue reading about the link between obesity, inflammation and weight loss.

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