Tag Archive for 'insulin'

Inflammation and obesity linked again


Regular readers of the Optimal Body Weight News & Reviews column may remember articles on the Zone Diet and the Perricone Weight Loss Diet, where the authors of these anti-inflammatory diets explained that obesity and inflammation go hand in hand. There may be differences in interpretation as to how it comes about, and the best approach to address it; but they both recognize the link between inflammation and obesity.

In both of these books, links between obesity and a number of diseases, including general fatigue, headaches, cancers and arthritis are also highlighted. Please note that while these two (Zone and Perricone) diets are discussed in this article about the link between inflammation and obesity, they are not necessarily the only two anti-inflammatory diets on the market, merely two of the more well-known weight loss programs focused on inflammation.

Now, it appears that a new study published in the April 2009 issue of “Cell Metabolism” may support at least some of these claims. While this study does not even touch on the effectiveness of any of the anti-inflammatory diets with regards to weight loss, it found clear evidence that an inflammatory chemokine (structurally related signaling proteins that are secreted by cells) called “CXCL5” rises and falls with obesity and subsequent weight loss in humans, and of course…mice.

This same inflammatory factor was already linked in previous studies to several diseases, including pulmonary disease, lung cancer, and arthritis. Now that it is also so clearly linked to obesity, it is also very likely that it may be responsible for insulin resistance that accompanies obesity.
Continue reading about the link between obesity, inflammation and weight loss.

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Flat Belly…and eating chocolates?


This sounds just too good to be true. A cure for belly fat! Weight loss of up to 15 pounds in 32 days, without performing a single crunch! Hard to believe? But then, it is always important to keep an open mind…you never know. This is what all the fuss around the Flat Belly Diet is about….

The Flat Belly Diet has been one of the top selling diet books this year. It was written by Liz Vaccariello, editor in chief of Prevention, along with Cynthia Sass, MPH, RD, nutrition director at Prevention. The main focus area of this book is well chosen. Who doesn’t want a flat stomach?

The Flat Belly diet is in essence nothing other than a calorie controlled Mediterranean style diet, which has long been known to provide health benefits. So what made it so successful?
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In the near future – a real and healthy weight loss pill?!

Brittany Sauser (for MIT Technology Review) wrote a very interesting article on what may potentially be the silver bullet we are all hoping for! This new drug, developed by Sirtris Pharmaceuticals, is referred to as SRT1720, and it delivers all the health benefits of diet and exercise without any of the effort!

European scientists, led by professor Johan Auwerx at Ecole Polytechnique Federale de Lausanne (EPFL), in Switzerland, have found that mice fed on a high-fat, high-calorie diet and prevented from exercising regularly, can be protected against weight gain and metabolic disorders when given SRT1720. The treatment even increases the animals’ running endurance and reduced cholesterol levels.
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Review of the Perricone Diet


Dr Nicolas Perricone M.D. is probably best known for his guest appearances on television shows such as Oprah, CNN, the Today Show, and Larry King. He is a respected physician, a research scientist, and a trusted expert on health and beauty. In addition, he is also the author of three New York Times # 1 Best Sellers, “The Perricone Promise” (Warner Books 2004), “The Perricone Prescription” (HarperCollins 2002), as well as the New York Times best seller, “The Perricone Weight Loss Diet” (Random House 2005).

Perricone achieved tremendous success with his book “The Perricone Promise”, which really tapped into one of mankind’s most basic fears, that of getting old. Many customers reported that they looked and felt younger following Dr Perricone’s diet, and that it delivered an added bonus…they lost weight! Dr Perricone subsequently expanded his portfolio of programs with his anti-inflammatory weight loss program that promises to accelerate fat loss by increasing the metabolism and building and maintaining muscle mass, while at the same time making you look younger and live longer.

In his books he explains to his readers how to lose weight, rebuild muscle mass, while avoiding the haggard, aging, and drawn appearance that typically results from many of the other weight-loss programs. “Treat yourself well and the weight will come off,” he suggests. As an added bonus, Dr. Perricone’s program will help you sleep better; you will have more energy and less stress, and experience greater mental clarity. Lose the weight, the wrinkles, and the years! He goes on to promise dramatic results in as little as 14 days.
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An overview of the Zone Diet

Dr Barry Sears, a biochemist, first popularized the Zone diet in his 1995 book, “The Zone”. While this diet has not been developed specifically for weight loss, it is probably more well-known for its weight loss benefits than for any of the other advantages it promises, all thanks to solid media exposure. The popularity of this diet reached its peak in the late 1990s, slipped a bit, and then made a comeback recently following the endorsements of Hollywood A-listers and models such as Jennifer Aniston, Sarah Jessica Parker, Sandra Bullock and Cindy Crawford.

The Zone diet is often classified as a low-carb diet, but Dr Sears describes it as a moderate carb, moderate fat, and moderate protein diet, and regards it as superior to low-carb diets due to the improved hormonal responses. He goes on to say that the Zone diet can not be regarded as a protein rich diet since you never consume more low-fat protein during any meal than you can fit on the palm of your hand.

Many scientific studies are finding that weight management is a lot more complex than simply balancing calorie intake and calorie usage. The Zone approach suggests that inflammation precedes obesity. If that is true, any obesity problem can only be addressed by resolving the underlying inflammation.
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